10 research outputs found

    Trust predicts COVID-19 prescribed and discretionary behavioral intentions in 23 countries

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    The worldwide spread of a new coronavirus (SARS-CoV-2) since December 2019 has posed a severe threat to individuals well-being. While the world at large is waiting that the released vaccines immunize most citizens, public health experts suggest that, in the meantime, it is only through behavior change that the spread of COVID-19 can be controlled. Importantly, the required behaviors are aimed not only at safeguarding one s own health. Instead, individuals are asked to adapt their behaviors to protect the community at large. This raises the question of which social concerns and moral principles make people willing to do so. We considered in 23 countries (N = 6948) individuals willingness to engage in prescribed and discretionary behaviors, as well as country-level and individual-level factors that might drive such behavioral intentions. Results from multilevel multiple regressions, with country as the nesting variable, showed that publicized number of infections were not significantly related to individual intentions to comply with the prescribed measures and intentions to engage in discretionary prosocial behaviors. Instead, psychological differences in terms of trust in government, citizens, and in particular toward science predicted individuals behavioral intentions across countries. The more people endorsed moral principles of fairness and care (vs. loyalty and authority), the more they were inclined to report trust in science, which, in turn, statistically predicted prescribed and discretionary behavioral intentions. Results have implications for the type of intervention and public communication strategies that should be most effective to induce the behavioral changes that are needed to control the COVID-19 outbreak

    Zur Rolle von Selbstkonzept und social gadgets nach sozialem Ausschluss

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    Eyssel FA, Pfundmair M, Graupmann V, Frey D, Aydin N. Zur Rolle von Selbstkonzept und social gadgets nach sozialem Ausschluss. Presented at the 15. Fachgruppentagung Sozialpsychologie, Symposium „Sozialer Ausschluss“, Potsdam

    <i>Coccidioides</i> Endospores and Spherules Draw Strong Chemotactic, Adhesive, and Phagocytic Responses by Individual Human Neutrophils

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    <div><p><i>Coccidioides</i> spp. are dimorphic pathogenic fungi whose parasitic forms cause coccidioidomycosis (Valley fever) in mammalian hosts. We use an innovative interdisciplinary approach to analyze one-on-one encounters between human neutrophils and two forms of <i>Coccidioides posadasii</i>. To examine the mechanisms by which the innate immune system coordinates different stages of the host response to fungal pathogens, we dissect the immune-cell response into chemotaxis, adhesion, and phagocytosis. Our single-cell technique reveals a surprisingly strong response by initially quiescent neutrophils to close encounters with <i>C</i>. <i>posadasii</i>, both from a distance (by complement-mediated chemotaxis) as well as upon contact (by serum-dependent adhesion and phagocytosis). This response closely resembles neutrophil interactions with <i>Candida albicans</i> and zymosan particles, and is significantly stronger than the neutrophil responses to <i>Cryptococcus neoformans</i>, <i>Aspergillus fumigatus</i>, and <i>Rhizopus oryzae</i> under identical conditions. The vigorous <i>in vitro</i> neutrophil response suggests that <i>C</i>. <i>posadasii</i> evades <i>in vivo</i> recognition by neutrophils through suppression of long-range mobilization and recruitment of the immune cells. This observation elucidates an important paradigm of the recognition of microbes, i.e., that intact immunotaxis comprises an intricate spatiotemporal hierarchy of distinct chemotactic processes. Moreover, in contrast to earlier reports, human neutrophils exhibit vigorous chemotaxis toward, and frustrated phagocytosis of, the large spherules of <i>C</i>. <i>posadasii</i> under physiological-like conditions. Finally, neutrophils from healthy donors and patients with chronic coccidioidomycosis display subtle differences in their responses to antibody-coated beads, even though the patient cells appear to interact normally with <i>C</i>. <i>posadasii</i> endospores.</p></div

    Coccidioidomycosis: Epidemiology, Fungal Pathogenesis, and Therapeutic Development

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